Institute of Biomedical Materials and Devices

DATEDecember 31, 2022

Research Interests

Nanobio and Nanomedical Science


1. Shili Gai, Chunxia Li, Piaoping Yang*, Jun Lin*. Recent progress in rare earth micro/nanocrystals: soft chemical synthesis, luminescent properties, and biomedical applications. Chemical Reviews. 2014, 114(4): 2343-2389.

2. Yunlu Dai, Haihua Xiao, Jianhua Liu, Qinghai Yuan, Ping’an Ma*, Dongmei Yang, Chunxia Li, Ziyong Cheng, Zhiyao Hou, Piaoping Yang*, Jun Lin*. In vivo multimodality imaging and cancer therapy by near-infrared light-triggered trans-platinum pro-drug-conjugated upconverison nanoparticles. Journal of the American Chemical Society. 2013, 135(50): 18920-18929.

3. Piaoping Yang, Shili Gai, Jun Lin*. Functionalized mesoporous silica materials for controlled drug delivery. Chemical Society Reviews. 2012, 41(9): 3679-3698.

4. Shuming Dong, Yushan Dong, Bin Liu, Jing Liu, Shikai Liu, Zhiyu Zhao, Wenting Li, Boshi Tian, Ruoxi Zhao, Fei He*, Shili Gai, Ying Xie, Piaoping Yang*, Yanli Zhao*. Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy. Advanced Materials. 2022, 34(7): 2107054.

5. Yushan Dong, Shuming Dong, Bin Liu, Chenghao Yu, Jing Liu, Dan Yang*, Piaoping Yang*, Jun Lin*. 2D Piezoelectric Bi2MoO6 Nanoribbons for GSH-Enhanced Sonodynamic Therapy. Advanced Materials. 2021, 33(51): 2106838.

6. Bin Liu, Shuang Liang, Zhao Wang, Qianqian Sun, Fei He, Shili Gai, Piaoping Yang*, Ziyong Cheng*, Jun Lin*. A Tumor-Microenvironment-Responsive Nanocomposite for Hydrogen Sulfide Gas and Trimodal-Enhanced Enzyme Dynamic Therapy. Advanced Materials. 2021, 33(30): 2101223.

7. Shuming Dong, Yushan Dong, Tao Jia, Shikai Liu, Jing Liu, Dan Yang, Fei He*, Shili Gai, Piaoping Yang*, Jun Lin*. GSH-depleted nanozymes with hyperthermia-enhanced dual enzyme-mimic activities for tumor nanocatalytic therapy. Advanced Materials. 2020, 32(42): 2002439.

8. Bin Liu, Xiaoran Deng, Zhongxi Xie, Ziyong Cheng*, Piaoping Yang*, Jun Lin*. Thiol-Ene Click Reaction as a Facile and General Approach for Surface Functionalization of Colloidal Nanocrystals. Advanced Materials. 2017, 29(36), 1604878.

9. Qianqian Sun, Zhao Wang, Bin Liu, Fei He, Shili Gai, Piaoping Yang*, Dan Yang, Chunxia Li*, Jun Lin*. Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy. Coordination Chemistry Reviews. 2022, 451: 214267.

10. Jiating Xu, Jiajia Zhou, Yinghui Chen, Piaoping Yang*, Jun Lin*. Lanthanide-activated nanoconstructs for optical multiplexing. Coordination Chemistry Reviews. 2020,415: 213328.

11. Xudong Zhao, Xianglong Kong, Zhiliang Liu*, Zhi Li, Zewei Xie, Zhuoyan Wu, Fei He, Xinghua Chang, Piaoping Yang*, Jie Zheng*, Xingguo Li. The cutting-edge phosphorus-rich metal phosphides for energy storage and conversion. Nano Today. 2021, 40: 101245.

12. Arif Gulzar, Jiating Xu, Chen Wang, Fei He*, Dan Yang, Shili Gai, Piaoping Yang*, Jun Lin*, Dayong Jin, Bengang Xing. Tumour microenvironment responsive nanoconstructs for cancer theranostic. Nano Today. 2019, 26: 16-56.

13. Zhiping Zhang, Rumin Li, Mengjie Wang, Yushi Li, Yongming Tong, Piaoping Yang*, Yujun Zhua*. Two steps synthesis of CeTiOx oxides nanotube catalyst: Enhanced activity, resistance of SO2 and H2O for low temperature NH3-SCR of NOx. Applied Catalysis B-Environmental. 2021, 282: 119542.

14. Jialing Zhou, Ruoxi Zhao, Yaqian Du, Shikai Liu, Wenting Li, Shili Gai, Fei He, Lili Feng*, Piaoping Yang*. A Si-CdTe Composite Quantum Dots Probe with Dual-Wavelength Emission for Sensitively Monitoring Intracellular H2O2. Advanced Functional Materials. 2022, 32(20):2112083.

15. Yaqian Du, Rui Zhang, Jiani Yang, Shikai Liu, Jialing Zhou, Ruoxi Zhao, Fei He*, Yanqiao Zhang*, Piaoping Yang*, Jun Lin*. A "Closed-Loop" Therapeutic Strategy Based on Mutually Reinforced Ferroptosis and Immunotherapy. Advanced Functional Materials. 2022, 32(13): 2111784.

16. Jiating Xu, Wei Han, Piaoping Yang*, Tao Jia, Shuming Dong, Huiting Bi, Arif Gulzar, Dan Yang, Shili Gai, Fei He*, Jun Lin*, Chunxia Li. Tumor microenvironment-responsive mesoporous MnO2-coated upconversion nanoplatform for self-enhanced tumor theranostics. Advanced Functional Materials. 2018, 28(36): 1803804.

17. Yanlin Zhu, Zhao Wang, Ruoxi Zhao, Yiheng Zhou, Lili Feng*, Shili Gai*, Piaoping Yang*. Pt Decorated Ti3C2TxMXene with NIR-II Light Amplified Nanozyme Catalytic Activity for Efficient Phototheranostics. ACS Nano. 2022, 16(2), 3105−3118.

18. Bin Liu, Yulong Bian, Shuang Liang, Meng Yuan, Shuming Dong, Fei He, Shili Gai, Piaoping Yang*, Ziyong Cheng*, Jun Lin*. One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy. ACS Nano. 2022, 16(1), 617−630.

19. Lu Yang, Haixia Zhu, Ruoxi Zhao, Zhijia Zhang, Bin Liu, Haijiang Gong, Yanlin Zhu, He Ding, Shili Gai, Lili Feng*. Tumor microenvironment activated glutathione self-depletion theranostic nanocapsules for imaging-directed synergistic cancer therapy. Chemical Engineering Journal. 2022, 450(2), 138137.

20. Bin Liu, Yulong Bian, Meng Yuan, Yanlin Zhu, Shikai Liu, He Ding, Shili Gai, Piaoping Yang*, Ziyong Cheng*, Jun Lin*. L-buthionine sulfoximine encapsulated hollow calcium peroxide as a chloroperoxidase nanocarrier for enhanced enzyme dynamic therapy. Biomaterials. 2022, 289, 121746.

21. Zhao Wang, Tao Jia, Qianqian Sun, Ye Kuang, Bin Liu, Mengshu Xu, Hui Zhu, Fei He*, Shili Gai*, Piaoping Yang*. Construction of Bi/phthalocyanine manganese nanocomposite for trimodal imaging directed photodynamic and photothermal therapy mediated by 808 nm light. Biomaterials. 2020, 228: 119569.

22. Boshi Tian, Chen Wang, Yaqian Du, Shuming Dong, Lili Feng*, Bin Liu, Shikai Liu, He Ding*, Shili Gai, Fei He, Piaoping Yang*. Near Infrared-Triggered Theranostic Nanoplatform with Controlled Release of HSP90 Inhibitor for Synergistic Mild Photothermal and Enhanced Nanocatalytic Therapy with Hypoxia Relief. Small. 2022, 18(28), 2200786.

23. Tao Jia, Zhao Wang, Qianqian Sun, Shuming Dong, Jiating Xu, Fangmei Zhang, Lili Feng, Fei He, Dan Yang, Piaoping Yang*, Jun Lin*. Intelligent Fe-Mn Layered Double Hydroxides Nanosheets Anchored with Upconversion Nanoparticles for Oxygen-Elevated Synergetic Therapy and Bioimaging. Small. 2020, 2001343.

24. Shikai Liu,§ Wenting Li,§ Yangyang Zhang, Jialing Zhou, Yaqian Du, Shuming Dong, Boshi Tian, Linyang Fang, He Ding*, Shili Gai*, Piaoping Yang*. Tailoring Silica-Based Nanoscintillators for Peroxynitrites-Potentiated Nitrosative Stress in Postoperative Radiotherapy of Colon Cancer. Nano Letters. 2022, 22(15), 6409-6417.

25. Jialing Zhou, Ruoxi Zhao, Shikai Liu, lili Feng, Wenting Li, Fei He, Shili Gai*, Piaoping Yang*. Europium doped silicon quantum dot as a novel FRET based dual detection probe: sensitive detection of tetracycline, zinc and cadmium. Small Methods. 2021, 5(10): 2100812.

26. Shuming Dong, Yushan Dong, Tao Jia, Fangmei Zhang*, Zhao Wang, Lili Feng, Qianqian Sun, Shili Gai, and Piaoping Yang*. Sequential Catalytic, Magnetic Targeting Nanoplatform for Synergistic Photothermal and NIR-Enhanced Chemodynamic Therapy. Chemistry of Materials. 2020, 32, 9868−9881.

27. Ye Kuang, Jiating Xu, Chen Wang, Tianyao Li, Shili Gai, Fei He, Piaoping Yang*, Jun Lin*. Fine-tuning Ho-based red-upconversion luminescence by altering NaHoF4 core size and NaYbF4 shell thickness. Chemistry of Materials. 2019, 31(19): 7898-7909.

28. Zhiliang Liu, Xiangxi Wang, Zhuoyan Wu, Sungjin Yang, Shaolei Yang, Shunpeng Chen, Xinteng Wu, Xinghua Chang, Piaoping Yang*, Jie Zheng*, Xingguo Li. Ultrafine Sn4P3 nanocrystals from chloride reduction on mechanically activated Na surface for sodium/lithium ion batteries. Nano Research. 2020, 13(11), 3157–3164.

29. Shuming Dong, Jiating Xu, Tao Jia, Mengshu Xu, Chongna Zhong, Guixin Yang, Jiarong Li, Dan Yang, Fei He, Shili Gai*, Piaoping Yang*, Jun Lin*. Upconversion- mediated ZnFe2O4nanoplatform for NIR-enhanced chemodynamic and photodynamic therapy. Chemical Science. 2019, 10(15): 4259-4271.

30. Tao Jia, Jiating Xu, Shuming Dong, Fei He*, Chongna Zhong, Guixin Yang, Huiting Bi, Mengshu Xu, Yingkui Hu, Dan Yang, Piaoping Yang*, Jun Lin*. Mesoporous cerium oxide-coated upconversion nanoparticles for tumor-responsive chemo-photodynamic therapy and bioimaging. Chemical Science. 2019, 10(37): 8618-8633.


1. Preparation of photoresponsive nanocomposites and research on integrated performance of diagnosis and treatment, Heilongjiang Provincial People's Government, Science and Technology Award (Natural Category), First Prize, 2020.12

2. Construction and anti-tumor properties of rare earth up-conversion luminescent materials, Heilongjiang Provincial People's Government, Science and Technology Award (Natural Category), First Prize, 2017.10

3. The 2nd Harbin Science and Technology Innovation Leader Award, Harbin Science and Technology Innovation Team Award Review Work Leading Group, 2016.12.31

4. Design and synthesis of multifunctional mesoporous materials with hollow shell structure and its application in the field of targeted and controlled drug release, Jilin Provincial Science and Technology Award Committee, Harbin Science and Technology Progress Award, third prize, Harbin Municipal People's Government 2016

5. Design and synthesis of new multifunctional drug carriers and its application in the field of targeted and controllable drug sustained release, Heilongjiang Provincial People's Government, Science and Technology Award (Natural Category), Second Prize, 2015.12

6. Controllable synthesis and surface functionalization of rare earth luminescent nanocrystals as fluorescent probes, Harbin Science and Technology Progress Award, first prize, Harbin Municipal People's Government, 2015.10

7. Design, synthesis and performance research of new micro-nano structured functional materials, Heilongjiang Provincial People's Government, Science and Technology Award (Natural Category), Second Prize, 2014.8


Lili Feng