The "liquid robot" was implanted into the affected region of mice that had been transplanted with breast cancer tumors. When exposed to 808nm near-infrared laser irradiation, the tumor inhibition rate reached an impressive 98.28%, with no apparent inflammation or damage observed post-treatment. This marks a groundbreaking advancement in the design, synthesis mechanism, and efficacy evaluation of photothermoelectric antitumor therapeutic agents, a milestone achieved for the first time.

The research findings indicate that, during photothermoelectric therapy, these nanoparticles can efficiently accumulate in mitochondria, deplete the protein that nourishes tumors, inhibit heat shock proteins, and present promising avenues for achieving precise and efficient tumor treatment. This expands new research and development pathways.

Recently, these significant accomplishments were published in the Science Advances sub-journal under the title "Mitochondria-targeting Cu3VS4 nanostructure with high copper ionic mobility for photothermoelectric therapy."

The synthetic procedure and the synergistic cancer PTET of CVS NPs are schematically represented.

In 2023, Professor YANG Piaoping's team, focusing on improving people's lives and health, deeply immersed themselves in basic scientific research. They systematically investigated the construction of tumor diagnosis and treatment systems, efficacy evaluation, and molecular mechanisms. The team achieved a series of innovative results, consistently making breakthroughs and securing publications in top journals.

Original link: https://www.science.org/doi/10.1126/sciadv.adi9980